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even though by looking online searches they state topamax and depakote don t work well together, i kinda believe is, due to the side effects of the med s becuase my son at the start of depakote he stop eating as much as he used too, now that we have been weaning off topamax he has been eating a lot more, and a lot more alert with everything else, and with the help of all his therapy s he has been receiving, he has been doing better.